A Synergistic System: Urolithin A, CoQ10, & PQQ

UA.01: The Advanced Mitochondrial Renewal Protocol

As early as age 30, the body’s ability to recycle damaged mitochondria, a process called Mitophagy, begins to decelerate. This leads to a buildup of "cellular debris," resulting in reduced ATP (energy) production and overall cellular resilience and longevity.

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The Bio-Availability Factor

Urolithin A is a rare postbiotic associated with mitophagy activation. However, research indicates that a majority of individuals may not possess the specific gut microbiome profile required to naturally convert dietary precursors into active Urolithin A at optimized levels.

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Cellular Maintenance Over Time

Natural mitochondrial quality-control capacity can fluctuate across the lifespan. This progression can lead to a shift in cellular efficiency markers and the natural accumulation of secondary metabolic byproducts within the cell.

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Mitochondrial Efficiency Markers

Efficient mitochondria are central to the natural synthesis of ATP. When cellular efficiency is prioritized, it supports sustained physical resilience and natural energy levels without the need for temporary stimulants.

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The Bio-Availability Factor

Urolithin A is a rare postbiotic associated with mitophagy activation. However, research indicates that a majority of individuals may not possess the specific gut microbiome profile required to naturally convert dietary precursors into active Urolithin A at optimized levels.

Image
Cellular Maintenance Over Time

Natural mitochondrial quality-control capacity can fluctuate across the lifespan. This progression can lead to a shift in cellular efficiency markers and the natural accumulation of secondary metabolic byproducts within the cell.

Image
Mitochondrial Efficiency Markers

Efficient mitochondria are central to the natural synthesis of ATP. When cellular efficiency is prioritized, it supports sustained physical resilience and natural energy levels without the need for temporary stimulants.

The TriPhase Mito System™ MOA

How UA.01 orchestrates cellular renovation through three distinct biological stages.

1

Urolithin A (UA): Mitophagy & Cellular Maintenance

Support the natural maintenance of cellular efficiency.

Urolithin A is studied for its role in supporting the PINK1/Parkin signaling pathway.

These units are identified and incorporated into natural recycling pathways, supporting overall cellular resilience.

Clinical data observed to support a significant increase in mitophagy markers.

2

Pyrroloquinoline quinone (PQQ): Mitochondrial Density & Longevity

Expand the cellular energy infrastructure.

Within the cellular environment, PQQ is studied for its role in the PGC-1α pathway, a key factor in mitochondrial maintenance.

This phase signals your cells to support the natural synthesis of new mitochondrial networks.

PQQ has been observed to be highly efficient in supporting redox cofactors during natural cellular cycles.

3

Coenzyme Q10 (CoQ10): The ATP Energy Factor

Support sustained energy maintenance.

The Electron Transport Chain (ETC) in the newly formed mitochondria is supported using Ubiquinol (CoQ10).

By facilitating efficient electron transfer, the system supports the natural synthesis of ATP, the fundamental unit of human energy, while maintaining low free radical levels.

Ubiquinol (the active ingredient of CoQ10) is shown to support the majority of total human cellular energy production.

Advanced Synergies: Urolithin A, CoQ10, and PQQ

We don't "label dress" with trace amounts. UA.01 is formulated with clinically relevant levels designed to match or exceed the levels used in peer-reviewed human research.

Urolithin A (500mg)

The Standard: 99% Pure Urolithin A.
The Rationale: This 500mg dosage aligns with levels utilized in clinical research evaluating mitophagic flux and markers of muscular endurance.

PQQ (20mg)

The Standard: High-stability Pyrroloquinoline Quinone.
The Rationale: 20mg is the recognized dosage utilized in research regarding mitochondrial density pathways and cognitive maintenance.

Coenzyme Q10 (240mg)

The Standard: USP-Grade Fermented CoQ10.
The Rationale: While most protocols offer 30–100mg, we utilize 240mg to provide comprehensive support for the factors involved in the electron transport chain.

The Network Synergy

The Standard: The TriPhase Mito System™ Integration.
The Rationale: UA.01 is engineered for Systemic Compounding. By coordinating markers of cellular clearance (UA), density (PQQ), and energy maintenance (CoQ10), this protocol supports a cumulative biological environment.

Relevant Endpoints: Peer-Reviewed Research on our Bio-Actives

Evidence-Based Outcomes: Clinical Data on Core Ingredients
Microscopic view of mitochondria in cells
Muscle Performance (Urolithin A)
In a double-blind, placebo-controlled human trial, participants taking 500mg of Urolithin A showed a potential for significant increase in muscle strength and a significant improvement in aerobic endurance over 4 months.
Inflammatory Markers (PQQ & UA)
Clinical subjects showed potential for a reduction in markers of systemic cellular stress.
Mitochondrial Turnover (The Protocol)
Biological data suggests that peak mitochondrial renovation occurs between days 60 and 90, matching our Biological Roadmap protocol.

Third-Party Validation Every batch of UA.01 undergoes rigorous testing for:

Purity

Verification of active compound concentrations via HPLC.

Safety

Screening for heavy metals (Lead, Mercury, Arsenic) and microbial contaminants.

Integrity

100% Glyphosate-free and Non-GMO.

See Current Certificate of Analysis (COA) PDF

Click Here to See our Most Recent COA

The information presented on this page is for educational purposes and reflects general biological processes observed in human research. Individual responses and timelines vary based on physiology, lifestyle, and baseline health. This content is not intended as medical advice.